بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناس ارشد، گروه تربیت بدنی و علوم ورزشی، دانشگاه پیام نور، صندوق پستی 3697-19395 تهران، ایران

2 عضو هیات علمی دانشگاه پیام نور

3 گروه فیزیولوژی ورزش ، دانشگاه پیام نور، تهران صندوق پستی 3697-19395، ایران.

چکیده
هدف و زمینه:هدف از پژوهش حاضر بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو بود.
روش پژوهش: 48 سر موش صحرایی نژاد ویستار 8-6 هفته ای با محدوده وزنی 26 ± 105 گرم خریداری و به طور تصادفی به 5 گروه کنترل (8 سر)،تزریق آب مقطر (10 سر)،تزریقNNK (10سر)،تمرین شنا (10 سر)،تمرین شنا + تزریق NNK (10سر)، تقسیم شدند. برنامه تمرینی شامل 12 هفته تمرین شنا با شدت زیر بیشینه (پنج روز در هفته) بود. 48 ساعت پس از آخرین جلسه تمرین نمونه‌گیری از بافت ریه انجام شد و سطوح نشانگرهای MAPK و MDA بافت ریه با تکنیک الایزا، اندازه گیری شد. جهت تجزیه و تحلیل داده ها از آنالیز واریانس یک طرفه و توکی استفاده شد.
نتایج: نتایج نشان داد میزان MAPK (001/0P= ) وMDA(000/0P= )در بین گروه ‌ها معنی دار بود.نتایج آزمون توکی نشان داد که کاهش MAPK در گروه‌های شنا و شنا + مداخله NNK نسبت به گروه مداخله NNK معنی‌دار بود(001/0=P)(001/0=P) و همچنین، میزان کاهش MDA در گروه-های شنا و شنا + مداخله NNK نسبت به گروه مداخله NNK معنی‌دار بود (001/0=P)(001/0=P).
نتیجه گیری:نتایج مطالعات نشان دادند،تمرین شنا می‌تواند تا حدودی آثار منفی NNK بر سطوح MAPK و MDA را کاهش دهد و این احتمال وجود دارد که با توجه به نقش ضدالتهابی فعالیت ورزشی شنا بتواند اثر کارسینوژنیک NNK را کنترل و در محافظت از سیستم تنفسی در برابر ماده سرطان‌زای NNK تاثیر گذار باشد.

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Fathi Bayyatiani Z, Dabidi Roshan V, Ayaz A, Hoseinzadeh M. The relationship between the pro-inflammatory markers with lipid peroxidation after water-based regular exercise and ginger supplement in breast cancer. Daneshvar Medicine. 2013;21(1):61-76.

فیزیولوژی ورزشی
دوره 14، شماره 56
بهمن 1401
صفحه 147-176

  • تاریخ دریافت 04 اردیبهشت 1401
  • تاریخ بازنگری 11 مهر 1401
  • تاریخ پذیرش 27 مهر 1401