Muscle Murf1 and P70S6K Before and After 6 Weeks of Resistance Training and HMB Supplementation in Inactive Men

Document Type : Research Paper

Authors
Seyed Mostafa Mousavi Mozafar 1
Maryam Nourshahi 2
Ali Akbarnejad 3
1 Ph.D. Student of Exercise Physiology, Shahid Beheshti University, Tehran
2 Associate Professor of Exercise Physiology, Shahid Beheshti University, Tehran
3 Associate Professor of Exercise Physiology, University of Tehran
10.22089/spj.2018.5770.1761
Abstract
Resistance training with HMB supplement helps preserving the body mass and, that is why, it is extensively practiced by athletes. However, there are contradictory results about the effect of the pathway of this supplement on increasing factors related to hypertrophy or reduction of atrophy. The present study investigates the effect of HMB and resistance training on response to Muscle MuRF1 and P70S6K in inactive men. To this end, 40 inactive men with the average age (25.5±5 years) and a BMI of (21.2±2 kg/m2) were divided into the following four training categories: training, training+HMB, HMB and control. The subjects did bodybuilding exercises (3set/10-12repitations/75%-80%1RM) for four days a week over a six-week time period. The control group did not do any kinds of exercise. The vastus lateralis muscle biopsy and 1RM amounts of each subject in leg press movement were conducted and measured before and after six weeks of training and consuming the supplement. The results of one-way ANOVA and repeated variance analysis test with inter-group factor showed that there is a difference (P= 0.001) between the increase of 1RM before and after six weeks of training and the amounts of P70S6K (P= 0.001) in all three groups in comparison with the control group. However, this difference was not significant (P= 0.22) in MuRF1 amounts. As a result, consuming HMB supplement in the course of training can lead to the increase of P70S6K response as a marker of hypertrophy and an increase of strength in the leg press after six weeks.
Keywords
Resistance Training
HMB Supplement
P70s6k
MuRF

Main Subjects

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Sport Physiology
Volume 12, Issue 45
Spring 2020
April 2020
Pages 79-94

  • Receive Date 02 July 2018
  • Revise Date 22 December 2018
  • Accept Date 28 December 2018