اثر ورزش بر بافت چربی بژ

نوع مقاله : مقاله مروری

نویسندگان
سمانه شیرخانی 1
سید محمد مرندی 2
فاطمه کاظمی نسب 3
کامران قائدی 4
فهیمه اسفرجانی 5
محمد حسین نصراصفهانی 6
1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران
2 گروه فیزیولوژی ورزشی ، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران
3 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه کاشان، کاشان، ایران
4 گروه زیست شناسی، دانشکده علوم، دانشگاه اصفهان، اصفهان، ایران
5 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، ایران
6 گروه زیست فناوری سلولی، مرکز تحقیقات علوم سلولی، پژوهشکده زیست فناوری جهاد دانشگاهی، پژوهشگاه رویان، اصفهان
10.22089/spj.2019.5561.1735
چکیده
چاقی منجر به ایجاد بیماری‌های متابولیک می‌شود و بافت چربی از تنظیم کننده‌های متابولیسم است. تحقیقات نشان می‌دهد برخی محرک‌ها منجر به بژ شدن بافت زیر پوستی می‌شوند، در نتیجه سلول‌ها دارای اثر گرمازائی و بسیاری از ویژگی های بافت چربی قهوه ‌ای می‌شوند. فعال شدن گیرنده های-β3 آدرنرژیک در بافت چربی قهوه‌ای که در اثر تمرینات ورزشی هم رخ می دهد منجر به فعال شدن UCP1 می‌شود و از موثرترین روش‌های مبارزه با افزایش وزن می‌باشد. از آنجا که ورزش یک مداخله ارزان در سبک زندگی است، و مزایای استفاده از تمرین بدنی به منظور بهبود و درمان غیردارویی بیماری های متابولیکی از جمله چاقی به خوبی نشان داده شده است، بررسی سازوکارهای مولکولی اثرات مثبت تمرین ضروری به نظر می رسد. از جمله این سازوکارهای مولکولی، افزایش ترموژنز به سبب انجام تمرینات ورزشی است که می تواند در اثر رهاسازی انواع سایتوکاین ها باشد. در اثر فعالیت بدنی UCP1 افزایش می یابد که به واسطه آن روند بژ شدن در انبارهای چربی سفید زیر پوستی رخ می دهد. افزایش سایتوکاین های مختلف و ژن های مهم درگیر در این روند که با انواع تمرینات در سطوح مختلف رخ می دهد نوید بخش این مسئله است که تمرینات ورزشی را می توان از جمله راه کار های احتمالی مبارزه با چاقی و سندروم متابولیک برشمرد.
کلیدواژه‌ها
بافت چربی بژ
ورزش
چاقی
گرمازائی
UCP1

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  • تاریخ دریافت 14 تیر 1397
  • تاریخ بازنگری 21 اسفند 1397
  • تاریخ پذیرش 25 اسفند 1397