تأثیر هشت هفته تمرین مقاومتی، استقامتی و موازی بر مقادیر سرمی CTRP-12، فورین، KLF-15، پروفایل لیپیدی و مقاومت به انسولین در مردان چاق غیرفعال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناسی‌ارشد فیزیولوژی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

2 دانشیار فیزیولوژی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

3 استاد بیوشیمی، دانشکدۀ پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران

چکیده

آدیپوکاین‌ها و بیومارکرهای التهابی، تسهیل کننده اثرات تخریبی چاقی نظیر مقاومت به انسولین هستند که در القای بیماری متابولیکی تقش بسزایی دارند. هدف پژوهش حاضر بررسی تاثیر ۸ هفته تمرین مقاومتی، استقامتی و موازی بر مقادیر سرمی CTRP-12، فورین، KLF-15 و مقاومت به انسولین در مردان چاق غیر فعال بود.40 مرد چاق غیرفعال (45ـ30 سال، BMI≥30) به طور تصادفی در 4 گروه، تمرین مقاومتی، تمرین استقامتی، تمرین موازی و کنترل تقسیم‌بندی شدند. گروه‌های تمرینی به مدت 8 هفته، سه جلسه در هفته به تمرینات ویژه پرداختند. مقادیر سرمی CTRP-12، فورین و KLF-15 با استفاده از کیت به روش ELISA اندازه‌گیری شد. برای تجزیه و تحلیل داده‌ها از آزمون آماری t همبسته و ANOVA در سطح معنا‌داری (05/0 ≥p) استفاده شد. نتایج آزمون t همبسته نشان داد که مقادیر KLF-15 گروه‌های تمرین هوازی (p=0.006) و موازی (p=0.036) به طور معناداری افزایش یافت. در حالی که، مقادیر فورین در این دو گروه کاهش معنا‌داری نشان داد (به ترتیب: p=0.001 p=0.044). مقادیر CTRP-12 نیز تنها در گروه تمرین موازی افزایش معنا‌داری (p=0.023) داشت. تمرین هوازی (p=0.009) و موازی (p=0.006) به طور معناداری مقاومت به انسولین را کاهش دادند. در بررسی بین گروهی تمرین هوازی تغییرات معنا‌داری در KLF-15 (p=0.039 و F=3.090) و فورین (p=0.031 و p=3.297) نسبت به گروه کنترل ایجاد کرد. به نظر می‌رسد استفاده از تمرینات هوازی و به ویژه تمرینات موازی تاثیرات بهتری بر پروفایل لیپیدی و همچنین آپریگولیشن آدیپوکاین‌های ضد التهابی جدید نظیر KLF-15 و CTRP-12 و همچنین دانرگولیشن آدیپوکاین التهابی فورین داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 8 weeks of resistance, endurance, and concurrent training on serum CTRP-12, Furin, KLF-15, lipid profiles and insulin resistance in sedentary obese men

نویسندگان [English]

  • najmadin Espandar 1
  • asghar tofighi 2
  • Javad Tolouei Azar 2
  • Mohammad Hasan Khadem Ansari 3
1 M.Sc. of exercise physiology, Urmia University
2 Associate Professor of Exercise Physiology, Urmia University
3 Professor of Biochemistry, Urmia University of Medical Sciences
چکیده [English]

Adipokine and inflammatory biomarkers, facilitate the degradation effects of obesity, such as insulin resistance that, are susceptible to induction of metabolic disease. The purpose of the present study was to investigate the effect of 8 weeks of resistance, endurance and concurrent training on serum CTRP-12, Furin, KLF-15 and insulin resistance in sedentary obese men. 40 inactive obese men (30-45 yrs, BMI≥30) were randomly divided into 4 groups, resistance training, endurance training, concurrent training, and control. The training groups trained for 8 weeks, three sessions a week. Serum levels of CTRP-12, Furin and KLF-15 were measured using ELISA kits. Data were analyzed by t-test and ANOVA at the significance level (p ≤ 0.05). The result of dependent t-test showed that KLF-15 values of endurance training groups (p = 0.006) and concurrent (p = 0.036) significantly increased. However, furin values in these two groups showed a significant decrease (p = 0.001 and p = 0.044, respectively). The values of CTRP-12 were only significant increase in the concurrent training group (p = 0.023). endurance (p = 0.009) and concurrent (p = 0.006) groups have significantly decreased in insulin resistance. In the intergroup analysis, aerobic training induces a significant cheange in KLF-15 (P = 0.039) and furin (p = 0.031) compared to control group. It seems that the use of endurance training, and in particular concurrent training, has a better effect on lipid profiles, as well as the upregulation of new anti-inflammatory adipokines such as KLF-15 and CTRP-12, and downregulatin of inflammatory adipokine furin

کلیدواژه‌ها [English]

  • Resistance Training
  • Endurance training
  • Concurrent training
  • CTRP-12
  • Furin
  • KLF-15

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فیزیولوژی ورزشی
دوره 13، شماره 49
بهار 1400
صفحه 107-136

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سابقه مقاله

  • تاریخ دریافت: 23 اردیبهشت 1398
  • تاریخ بازنگری: 26 شهریور 1398
  • تاریخ پذیرش: 03 مهر 1398

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