مقایسه یک دوره تمرین تناوبی خیلی شدید و تداومی بر پروتئین SIRT3 و دفاع ضد اکسایشی عضله دوقولوی رت های ماده سالمند

نوع مقاله : مقاله پژوهشی

نویسندگان
علی عسکریان 1
عباسعلی گائینی 2
محمدرضا کردی 3
سیروس چوبینه 4
1 گروه فیزولوژی ورزشی، دانشکده تربیت بدنی وعلوم ورزشی، دانشگاه تهران، تهران، ایران
2 هیئت علمی دانشگاه تهران
3 هیات علمی، دانشگاه تهران
4 دانشگاه تهران
10.22089/spj.2020.9044.2040
چکیده
هدف: هدف از پژوهش حاضر مقایسه 12 هفته تمرین تناوبی خیلی شدید و تداومی بر مقادیر پروتئین سیرتوئین3 (SIRT3) و فعالیت آنزیم سوپراکسیددیسموتاز عضله دوقولوی رتهای ماده سالمند بود. روش‌ها: 15 سر رت ماده نژاد ویستار (سن 18 ماه، وزن 17.34± 281 گرم) انتخاب و در سه گروه تمرین تناوبی خیلی شدید (HIIT)، تمرین تداومی (CT) و کنترل طبقه بندی شدند. پس از ارزیابی حداکثر اکسیژن مصرفی رتها، تمرینهای تناوبی خیلی شدید و تداومی به شکل پیشرونده و به ترتیب با شدت 85-90 % و 65-70% VO2max به گونه‌ای طراحی شدند که زمان HIIT تقریبا نصف زمان CT بود. 48 ساعت پس از آخرین جلسه تمرین، رت ها قربانی شدند و عضله دوقولوی آنها برای تجزیه و تحلیل های آزمایشگاهی ذخیره شد. یافته ها: پژوهش حاضر تفاوت معناداری را در مقادیر SIRT3 بین گروه های HIIT و کنترل و CT و کنترل (کنترل
کلیدواژه‌ها
تمرین
سالمندی
سیرتوئین‌ها
رادیکال‌های آزاد
دفاع ضد اکسایشی

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فیزیولوژی ورزشی
دوره 14، شماره 55
آذر 1401
صفحه 49-70

  • تاریخ دریافت 18 خرداد 1399
  • تاریخ بازنگری 13 مهر 1399
  • تاریخ پذیرش 21 مهر 1399