نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی، دانشگاه شهید بهشتی
2 استاد مرکز تحقیقات علوم اعصاب، دانشگاه علوم پزشکی شهید بهشتی
3 استادیار فیزیولوژی ورزشی، دانشگاه شهید بهشتی
چکیده
حفظ ساختار و عملکرد مغز در طول زندگی از اهمیت بالایی برخوردار است. فرآیندهای کلیدی توسعه مغزی در دوره-های بحرانی رشد به ویژه در دوره پیش از بلوغ برجسته هستند. از این رو مداخلات محیطی در طی این دوره حساس رشدی، ممکن است به تغییرات قابل توجه و ماندگار در ساختارهای در حال رشد مانند هیپوکمپ منجر شوند. در این مطالعه، تاثیر تمرین ترکیبی و بازی در محیط غنی شده پیش از بلوغ بر ساختار هیپوکمپ موش های صحرایی بزرگسال مورد ارزیابی قرار گرفت. بدین منظور، تحقیق به صورت طولی انجام شد و 27 سر موش صحرایی نر پس از دوره شیردهی به سه گروه تمرین ترکیبی، بازی در محیط غنی‌شده و کنترل تقسیم شدند. مداخلات به مدت سه هفته در دوران قبل از بلوغ (48-28 روزگی) اجرا شدند و در ادامه تا دوره بزرگسالی (85-48 روزگی) همه حیوانات بدون مداخله درون قفس-های استاندارد نگهداری شدند. پس از این دوران، مراحل تشریح و بافت‌برداری هیپوکمپ انجام شدند. روش وسترن بلات برای اندازه‌گیری عامل رشد عصبی مشتق از مغز (BDNF) و رنگ‌آمیزی نیسل برای ارزیابی تعداد سلول‌ها در نواحی هیپوکمپ استفاده شدند. نتایج آزمون آنوا یک‌طرفه نشان دادند که سطوح پروتئین BDNF (P
کلیدواژه‌ها
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