1.      Dobson R, Giovannoni G. Multiple sclerosis–a review. Eur J Neurol. 2018;26(1):27-40.

1. Sengul HS, Şengul Y, Yucel S, Forta H. Cognitive impairment in young multiple sclerosis and essential tremor patients: a comparative study. J Neurol.  2016;22(3):109-13.
2. McMurran CE, Zhao C, Franklin RJM. toxin-based models to investigate demyelination and remyelination. In: Lyons D, Kegel L. editors. Oligodendrocytes: methods in molecular biology. Humana Press, New York, NY; 2019. pp. 377-96.
3. Kim DS, Kim JY, Han Y. Curcuminoids in neurodegenerative diseases. Recent Pat CNS Drug Discov. 2012;7(3):184-204.
4. DeLuca GC, Yates RL, Beale H, Morrow SA. Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic. Brain Pathol. 2015;25(1):79-98.

6.       Kumar N,  Sharma N, Khera R, Gupta R,  Mehan S. Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain. Metab Brain Dis. 2020;36:911-25.

7.      Kuypers NJ, James KT, Enzmann GU. Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord‏. Exp Neurol. 2013;247:615-22.

1. Bondan E, Lallo M, Trigueiro A, Ribeir C, Sinhorini I, Graça D. Delayed Schwann cell and oligodendrocyte remyelination after ethidium bromide injection in the brainstem of Wistar rats submitted to streptozotocin diabetogenic treatment. Braz J Med Biol Res. 2006;39(5):637–46.
2.  Abdel-Salam OME, Khadrawy  YA, Mohammed NA, Youness ER. The effect of  gabapentin on oxidative stress in a model of toxic demyelination in rat brain. J Basic Clin Physiol Pharmacol. 2012;23(2):61-8.
3. Goudarzvand M, Choopani S, Shams A, Javan M, Khodaii Z, Ghamsari F, et al. Focal injection of EB as a simple model to study cognitive deficit. Basic Clin Neurosci. 2016;7:63–72.
4. Garabadu D, Singh D. Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats. Metab Brain Dis. 2020;35(3):483-95.
5.  Emeterio EPS, Tramullas M, Hurlé MA. Modulation of apoptosis in the mouse         brain after morphine treatments and morphine withdrawal. J Neuroscie. 2006;83(7):1352-61.
6.  Carlsohn A, Rohn S, Bittmann F, Raila J, Mayer F, Schweigert FJ.  Exercise increases the plasma antioxidant capacity of adolescent athletes. Ann Nutr Metab. 2008;53(2):96-103.

1. Stranahan A.M, Khalil D, Gould E. Running Induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus. 2007;17:1017–22.
2. Burghardt PR, Pasumarthi RK, Wilson MA, Fadel J. Alterations in fear conditioning and amygdalar activation following chronic wheel running in rats. Pharmacol Biochem Behav. 2006;84:306–312.
3. Nichol K, Deeny SP, Seif J, Camaclang K, Cotman CW. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement. 2009;5(4):287–94.
4.  Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, et al. Cardiorespiratory fitness attenuates the influence of amyloid on cognition. J Int Neuropschol Soc. 2015;21(10):841–50.
5.  Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L. Exercise training increases size of hippocampus and improves memory. Arq Neuropsiquiatr.  2011;108(7):3017-22.
6.  Micheli L, Ceccarelli M, D'Andrea G, Tirone F.  Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise. Brain Res Bull. 2018;143:181-93. 
7. Loprinzi PD, Day S, Deming R. Acute exercise intensity and memory function: evaluation of the transient hypofrontality hypothesis. Medicina. 2019;55(8):445.
8. Labban JD, Etnier JL. The effect of acute exercise on encoding and consolidation of long-term memory. J Sport Exerc Psychol. 2018;40:336–42.
9. Rathore A, Lom B. The effects of chronic and acute physical activity on working memory performance in healthy participants: A systematic review with meta-analysis of randomized controlled trials. Syst Rev. 2017 6:124.
10. Bromley-Brits K, Deng Y, Song W.  Morris water maze test for learning and memory deficits in Alzheimer's disease. J Vis Exp. 2011; (53):2920.
11. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16(2):109-10.
12. Pasupuleti MK, Molahally S.S, Salwaji S. Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives. J Indian Soc Periodontol. 2016;20(4):360–8.

1. Paxinos G, Watson C. The rat brain in stereotaxic coor­dinates: hard cover edition.  Cambridge: Academic Press; 2006.
2.  Goudarzvand M, Choopani S, Shams A, Javan M, Khodaii Z, Ghamsari F, et al. Focal injection of ethidium bromide as a simple model to study cognitive deficit and its improvement. Basic a Clin Neuroscie. 2016;7(1):63-73.
3.  Lee MH. Treadmill exercise enhances nitricoxide synthase expression in the hippocampus of food-deprived rats. Nutr Res. 2005;25:771-9.
4. Redila VA, Christie BR. Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus. Neurosci. 2006;137:1299–307.
5. Stranahan AM, Khalil D, Gould E. Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocamp. 2007;17:1017–22.
6.  Giralt A, Saavedra A, Carretón O, Xifró X, Alberch J, Pérez-Navarro E. Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease. Human molecular genetics. 2011;20(21):4232-47.

32.   Aghayi Nojedeh S, Hatami Nemati H, Malek Ahmadi M, Banan Khojasteh SM, Ahmadi H. The effect of Bacopa monnieri on spatial memory impairment and lipid peroxidation induced by local injection of ethidium bromide in the hippocampus of rat. J Animal Res. 2021;34(1):28-41.

1.  Nassar CCS, Bondan E, Alouche SR. Effects of aquatic exercises in a rat model                                                                                                                                                             of brainstem demyelination with ethidium bromide on the beam walking test. Arq Neuropsiquiatr. 2009;67(3A):652-6.

1.  Rhimluoye ZM,  Alihemati AR,  Hatami Nemati H, Hatam Ahmadi H. The effect of NO system on ethidium bromide-induced oxidative stress in the hippocampal formation of male rats. J Inflam Diseas. 2019;23(3):190-201.
2.  Mello PB, Benetti F, Cammarota M, lzquierdo I. Effects of acute and chronic physical exercise and stress on different types of memory in rats. An Acad Bras Cienc. 2008;80(2):301-9.
3. Anderson BJ, Rapp DN, Baek DH, McCloskey DP, Coburn-Litvak PS, Robinson JK. Exercise influences spatial learning in the radial arm maze. Physiol Behav. 2000;70:425–9.
4. Ang ET, Wong PT, Moochhala S, Ng YK, 2003. Neuroprotection associated with running: is it a result of increased endogenous neurotrophic factors? Neuroscie. 2003;118:335–45.
5.  Anga E-T, Daweb GS, Wong PTH, Moochhala S, Ng Y-K. Alterations in spatial learning and memory after forced exercise. Brain Reaserch. 2006;1113(1):186-93.
6. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM. Et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA. 2007;104:5638–43.
7. Rex CS, Lauterborn JC, Lin CY, Kramar EA, Roger GA, Gall CM, et al. Restoration of long-term potentiation in middle-aged hippocampus after induction of brain- derived neurotrophic factor. J Neurophysiol. 2006;96:668-677.
8. Braszko JJ, Kamin Ski KA, Hryszko T, Jedynak W, Brzo Sko S. Diverse effects of prolonged physical training on learning of the delayed nonmatching to sample by rata. Neuroscie Res. 2001;39:79-84.
9.  Lautenschlager NT, Almeida OP. Physical activity and cognition in old age. Curr Opin Psychiatry. 2006;19:190–3.
10.  Longoni G, Rocca MA, Pagani E, et al. Deficits in memory and visuospatial learning correlate with regional hippocampal atrophy in MS. Brain Struct Funct 2015;220:435–44.
11. Carvalho FB, Gutierres JM, Bohnert C, Zago AM, Abdalla FH, Viira JM, et al. Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination. J Nutr Biochem. 2015;26:378–90.

45.  Ghaffari Sh, Hatami H, Dehghan Gh. Saffron ethanolic extract attenuates oxidative stress, spatial learning, and memory impairments induced by local injection of ethidium bromide. Res Pharm Sci. 2015;10(3):222–32.

1. Morris JK, Vidoni ED, Johnson DK, Van Sciver A, Mahnken JD, Honea RA, et al. Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial. PloS One. 2017;10(12):e0170547.
2. Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2015;4:CD006489.

1.  Paillard T, Rolland Y, de Souto Barreto P. Protective effects of physical exercise in Alzheimer’s disease and parkinson’s disease: a narrative review. J Clin Neurol. 2015;11(3):212–9.